The ImplaVax Needle-Free Delivery Device

The Universal Vaccine Implant (UVI), which is pre-loaded during manufacturing in a sterile single use disposable cassette, is delivered using Enesi Pharma’s proprietary needle-free, multi-use (up to 1,000 times), spring-loaded actuator to facilitate reliable needle-free delivery in a pain-free manner. In our first human factors study, we found that the ImplaVax® platform was preferred (93%) by all groups of administrators, recipients and parents in comparison to a standard needle and syringe injection.

Additionally, a single use disposable system is in development where all three components are self-contained and could enable self-administration in the home setting. Both repeat use and single use systems do not require the use of glass vials, separate diluent or multiple needles and syringes.

Each UVI is delivered transcutaneously 2.5 – 7mm into the dermis, which has been shown in pre-clinical studies to be as least as effective as intramuscular or subcutaneous delivery routes. This is because the dermal and the sub-cutaneous region of the skin are rich in dendritic cells which are responsible for presenting antigens to the immune system.

You can watch ImplaVax® in action here

The ImplaVax Needle-Free Delivery Device